1. ç®ç
æ¬èšåºè©Šéšã®ç®çã¯ïŒèªç¶çºçããç«äŒææ§è ¹èçïŒFIPïŒã«å¯ŸããMolnupiravirã®å®å šæ§ããã³æå¹æ§ãæ€èšããããšã§ãããæ¬å ±åã§ã¯ïŒæ¬è©Šéšã®æ¹æ³ïŒå®èšåºããŒã¿ïŒããã³çµå£æäžã«ããMolnupiravirã®ç«äŒææ§è ¹èçïŒFIPïŒã«å¯Ÿããæå¹æ§ã«é¢ããçµè«ãå ±åããã
2. ã€ã³ãããã¯ã·ã§ã³
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3. æ¹æ³
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éç¥çµã»çŒç§çšFIPïŒ10mg/kg PO SID1æ¥1åçµå£æäžïŒœ
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â | âç«ã®å¹Žéœ¢ | âç«ã®äœé(kg) | FIPã¿ã€ã | âç¶æ | âæ²»çéå§æ¥ |
âMT001 | 4 | 3.7 | ç¥çµç³» FIP | åçºãã | 2022幎6æ |
MT002 | 2 | 3 | ç¥çµç³» FIP | åçºãã | 2022幎6æ |
MT003 | 2 | 0.74 | ãŠã§ããFIP | æ°èŠçäŸ FIP | 2022幎7æ |
MT004 | 9 | 2.5 | ãŠã§ããFIP | æ°èŠçäŸ FIP | 2022幎7æ |
MT005 | 1 | 4 | çŒç§ããã³ç¥çµç§ã® FIP | åçºãã | 2022幎7æ |
MT006 | 2 | 4.3 | ãŠã§ããFIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022幎7æ |
MT007 | 3 | 3.8 | ç¥çµç³» FIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022幎7æ |
MT008 | 4 | 1.6 | ãã©ã€ FIP | æ°èŠçäŸ FIP | 2022幎7æ |
MT009 | 5 | 2.2 | ãŠã§ããFIP | æ°èŠçäŸ FIP | 2022 幎 8 æ |
MT010 | 11 | 5.8 | ãŠã§ããFIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT011 | 2 | 4.1 | ç¥çµç³» FIP | åçºãã | 2022 幎 8 æ |
MT012 | 10 | 1.8 | ç¥çµç³» FIP | æ°èŠçäŸ FIP | 2022 幎 8 æ |
MT013 | 2 | 3.8 | ãŠã§ããFIP | æ°èŠçäŸ FIP | 2022 幎 8 æ |
MT014 | 2 | 2.9 | ãã©ã€ FIP | æ°èŠçäŸ FIP | 2022 幎 8 æ |
MT015 | 3.5 | 2.9 | çŒç§ããã³ç¥çµç§ã® FIP | åçºãã | 2022 幎 8 æ |
MT016 | 5 | 5.8 | ãã©ã€ FIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT017 | 2 | 2.8 | ãŠã§ããFIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT018 | 2 | 3.4 | ãŠã§ããFIP | åçº | 2022 幎 8 æ |
MT019 | 2 | 4.1 | ãã©ã€ FIP | åçº | 2022 幎 8 æ |
MT020 | 1 | 4.9 | ãŠã§ããFIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 8 æ |
MT021 | 2 | 4.2 | ç¥çµç³» FIPâ | åçº | 2022 幎 8 æ |
MT022 | 3 | 3.2 | ãŠã§ããFIP | åçº | 2022 幎 8 æ |
MT023 | 2.9 | 4.2 | ãŠã§ããFIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 8 æ |
MT024 | 4 | 5.8 | ãŠã§ããFIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT025 | 1.5 | 3.4 | ç¥çµç³» FIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT026 | 1 | 1.4 | ç¥çµç³» FIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 8 æ |
MT027 | 2 | 2 | ç¥çµç³» FIP | åçº | 2022 幎 8 æ |
MT028 | 2 | 1.4 | ãŠã§ããFIP | åçº | 2022 幎 8 æ |
MT029 | 4 | 0.5 | ãã©ã€ FIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 8 æ |
MT030 | 2 | 4.9 | ãã©ã€ FIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 8 æ |
MT031 | 2 | 5 | ãŠã§ããFIP | åå¿ããªã/GSæ²»çãžã®é²è¡ãé ã | 2022 幎 9 æ |
MT032 | 9 | 4 | ãã©ã€ FIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 9 æ |
MT033 | 9 | 5.4 | ãŠã§ããFIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 9 æ |
MT034 | 1 | 2.9 | ç¥çµç³» FIP | æ°ãã FIP ã±ãŒã¹ | 2022 幎 9 æ |
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4. çµæããã³èå¯
4.1 æ²»çãçµäºããç«
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4.2 æ²»çæ瞟
è©Šéšãç¶ç¶ãã18é ã®ãã¡ã3é ã¯æ²»çéå§1é±é以å ã«éçåãªã©ã®å䜵çã«ããæ»äº¡ïŒMT001ãMT007ïŒãŸãã¯å®æ¥œæ»ïŒMT033ïŒã4é ç®ïŒMT005ïŒã¯æ²»çéå§4é±éåŸã«ç¡é¢ä¿ãšæãããçŒç ã«ããæ»äº¡ãããæ®ãã®14é ã¯èšç»ãããã§ãŒãºã«ãããã£ãŠæ²»çãç¶ç¶ãããå°ãªããšã2çžã®æ²»çãåãã14é ã®ç«ã¯ãæ¬æžçºè¡æïŒ2022幎12æïŒã«ãããŠããã¹ãŠå¥åº·ãªç¶æ ãç¶æããŠããŸãã
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4.3 奜ãŸããæ²»çå¹æã®ææš
4.3.1 äœé
æ²»çå¹æã®é·æçãªææšãšããŠæãåçŽãªãã®ã¯äœéã§ãã£ããæ¬è©Šéšã§ã¯ã14é äž11é ïŒ79ïŒ ïŒã§äœéã®å¢å ã芳å¯ããããæ²»çåãšæ²»çåŸã®ç«ã®äœéã®å€åãè¡š 2 ã«ç€ºãã
â | ééïŒååŠçïŒ | äœéïŒæ²»çåŸïŒ |
MT008 | 1.6 | 2.2 |
MT011 | 2 | 2.6 |
MT015 | 2.9 | 3.35 |
MT016 | 5.8 | 5.8 |
MT017 | 2.8 | 3.1 |
MT018 | 3.4 | 3.9 |
MT019 | 4.1 | 4.4 |
MT021 | 4.2 | 3.78 |
MT022 | 3.2 | 2.7 |
MT023 | 4.2 | 4.5 |
MT024 | 5.8 | 5.9 |
MT026 | 1.4 | 3 |
MT028 | 1.4 | 2.3 |
MT034 | 2.9 | 3 |
è¡š2: ã¢ã«ããã©ãã«ãçšããFIPæ²»çã®èšåºè©Šéšãçµäºããç«ã®æ²»çåãšæ²»çåŸã®äœéã
4.3.2 è¡æž èçœ
FIPã®ç«ã§ã¯ãè¡æž ç·èçœæ¿åºŠãæ£åžžããé«ããè¡æž ã°ãããªã³ãé«ããè¡æž ã¢ã«ããã³å€ãäœããA:Gæ¯ãäœãããšãé »ç¹ã«ã¿ããããæ¬è©Šéšã§ã¯ãæ²»çãå®äºãã14é äž10é ãå¿ èŠãªè¡æ¶²æ€æ»ãå®äºããŠããããããã®ç«ã®è¡æž ã¿ã³ãã¯å€ã¯æ¹åã瀺ããå°ãªããšã2æïŒ60æ¥ïŒã®æ²»çã§åŸã ã«æ£åžžå€ã«éããŠããŸãã
â | AGæ¯ç ååŠç | AGæ¯ç æ²»çåŸ | ã°ãããªã³ååŠç | ã°ãããªã³æ²»çåŸ |
MT011 | 0.8 | 0.9 | 40 | 34 |
MT016 | 0.5 | 0.5 | 50 | 48 |
MT017 | 0.4 | 0.4 | 53 | 50 |
MT018 | 0.4 | 0.63 | 58 | 39 |
MT019 | 0.5 | 0.8 | 51 | 43 |
MT022 | 0.8 | 0.8 | 43 | 41 |
MT023 | 0.4 | 0.4 | 60 | 60 |
MT024 | 0.4 | 0.5 | 76 | 69 |
MT026 | 0.5 | 0.6 | 54 | 44 |
MT034 | 0.4 | 0.5 | 72 | 55 |
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5. çµè«
æ¬èšåºè©Šéšã«ããïŒã¢ã«ããã©ãã«ã¯FIPç«ã®äžéšã®éå£ã«ãããŠïŒæ»²åºæ§ïŒãŠã§ããïŒããã³é滲åºæ§ïŒãã©ã€ïŒã®ç«äŒææ§è ¹èçïŒFIPïŒã«å¯Ÿããæå¹ãªæ²»çéžæè¢ã§ãããïŒå£ãããšã瀺ããããããããGS-441524ã§FIPVã®è€è£œãé»æ¢ã§ããªãå ŽåãMolnupiravirã¯æå¹ãªä»£æ¿FIPæ²»çæ³ã§ããã Molnupiravirã¯ããã³äŒææ§è ¹èçã®æ²»çã«åç¬ãŸãã¯GS-441524ãšäœµçšããŠäœ¿çšããããšãå¯èœã§ãã ä»åŸïŒFIPæ²»çã«ãããMolnupiravirã®åæ¥ç䜿çšã«åããŠïŒMolnupiravirã®çŽ°èæ¯æ§ã«é¢ãããã詳现ãªç 究ãè¡ãïŒå®å šæ§ã®æäžéã¬ã€ãã©ã€ã³ã確ç«ããå¿ èŠãããã
åè
Pedersen, NC., and Jacque, N. (2021). Alternative treatments for cats with FIP and natural or acquired resistance to GS-441524.
Pedersen, NC., Perron M., Bannasch, M., Montgomery, E., Murakami, E., Liepnieks, M., and Liu, H. (2019). Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. Journal of Feline Medicine and Surgery. 2019;21(4):271-281.
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